I'm Dr. Tiffany Fleet
Physician Scientist
- Location Maryland, Pennsylvania & Texas
- E-Mail tiffany.chantal87@gmail.com
Hello! I’m Dr Tiffany Fleet. I practice obesity medicine and study genetic variants associated with obesity.
Professional Skills (% used last 10 years)
(Total Professional Skills is percent of time spent equaling 100%)
Education
Postdoc
UNIVERSITY OF PENNSYLVANIA
Residency
THE HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA
Physician Scientist Program
Doctor of Medicine
Baylor College of Medicine, Houston, TX
Medical Scientist Training Program
Doctorate of Philosophy
Baylor College of Medicine, Houston, TX
Medical Scientist Training Program
Bachelor of Science
University of Maryland, Baltimore County, Baltimore, MD
Biochemistry and Molecular Biological Sciences
Magna cum laude
Phi Beta Kappa
Certificate
National Institutes of Health
Introduction to Principles & Practice of Clinical Research
Work & Research Experience
I practice obesity medicine and study metabolic disorders. Currently, I am assessing genetic variants associated with lipodystrophy in the UPHS system to define prevalence, perform deep phenotyping, and develop AI tools to diagnose lipodystrophy from EHR data.
Research Assistant
The University of Pennsylvania, Philadelphia, PA
Advisor: Mitchell Lazar, M.D., Ph.D., Institute for Diabetes, Obesity and Metabolism
I am elucidating the cistromic contribution of PPAR family members PPARa and PPARg in non-alcoholic fatty liver disease pathogenesis. Specifically, I am using genomic and molecular techniques to identify pathways perturbed with steatohepatitis.
Research Assistant
Baylor College of Medicine, Houston, TX
Advisor: Bert O’Malley, M.D., Professor, Molecular and Cellular Biology
I identified SRC-2 as an indispensable integrator of transcriptional complexes that control the rate-limiting steps of hepatic glucose release and accretion. This work resulted in a first author publication in Proceedings of the National Academy of Sciences of the United States of America.
Research Assistant
University of Maryland Baltimore County, Baltimore, MD
Advisor: Lasse Lindahl, Ph.D., Professor, Biological Sciences
I used molecular cloning to delineate steps in pre-ribosomal RNA processing by the endonuclease RNase MRP and the exonuclease XRN1.
Research Assistant
University of Alberta, Edmonton, Alberta, Canada
Mentor: Michele Barry, Ph.D., Professor, Medical Microbiology and Immunology
I evaluated the molecular mechanism(s)by which vaccinia virus evades host cell death via anti-apoptotic proteins A6L and N1L using molecular cloning.
Research Assistant
University of Maryland Baltimore County, Baltimore, MD
Advisor: Lasse Lindahl, Ph.D., Professor, Biological Sciences
I used structure function studies to determine the base pair conservation in the catalytic RNA helices of the ribozymes RNase MRP and RNase P.
Teaching Experience
• Lectured to second year medical students in the Cardinal Manifestations of Disease lecture series
• Assisted in planning and organizing the lecture series
Teaching Assistant
Baylor College of Medicine, Houston TX
• Assisted teaching the Energy and Metabolism graduate school course
Learning Assistant
University of Maryland Baltimore County, Baltimore, MD
• Assisted teaching physics to undergraduates
Tutor for Upward Bound
University of Maryland Baltimore County, Baltimore, MD
• Tutored first generation and low income high school students delineate steps in pre-ribosomal RNA processing by the endonuclease RNase MRP and the exonuclease XRN1.
PUBLICATIONS
Fleet, T., Stashi, E., Zhu, B., Rajapakshe, K., Marcelo, K. L., Kettner, N. M., Coarfa, C., Fu, L., O’Malley, B., York, B (2016). Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology. Journal of Biological Rhythms. 31(5), 443–460.
http://doi.org/10.1177/0748730416657921
Fleet, T., Zhang, B., Lin, F., Zhu, B., Dasgupta, S., Stashi, E., Tackett, B., Thevananther, S., Rajapakshe, K., Gonzales, N., Dean, A., Mao, J., Timchenko, N., Malovannaya, A., Qin, J., Coarfa, C., DeMayo, F., Dacso, C., Foulds, C., O’Malley, B., York, B. (2015). SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1519073112
Kesari, N., Fleet, T., Alanzi B., Goodman C. (2017) A 48-year-old Woman with Bizarre Behavior, Neurological Symptoms, and Progressive Decline. Neurology
LEADERSHIP EXPERIENCE & PROFESSIONAL SOCIETIES
Endocrine Society
USA
American Association for the Advancement of Science
USA
American Association of Clinical Endocrinology
USA
Medical Scientist Training Program Student Operating Committee
Baylor College of Medicine, Houston, TX
Graduate School Council
Baylor College of Medicine, Houston TX
National Youth Leadership Forum
Baylor College of Medicine, Houston TX
Student National Medical Association
Baylor College of Medicine, Houston TX
Mary Susan Moore Medical Society
Baylor College of Medicine, Houston TX
Introduction to Principles & Practice of Clinical Research
National Institutes of Health
Presentations
Chicago IL, 2016
SRC-2 Orchestrates Polygenic Inputs for Fine-tuning Glucose Homeostasis. (Oral presentation)
Cold Spring Harbor, NY 2014
SRC-2 Dynamically Regulates Gluconeogenesis and Glycolysis via Glucose-6-phosphatase and Glucokinase. (Poster Presentation)
Houston, TX 2015
SRC-2 Orchestrates Polygenic Inputs for Fine-tuning Glucose Homeostasis. (Oral presentation)
(Download CV to view additional presentations)
Honors, Awards and Achievements
T32 Endocrinology Diabetes and Metabolism 2021-present
NIDDK
Invited Chair of the Nuclear Receptors Panel at Endocrine Society Meeting 2024
Future Leaders Advancing Research in Endocrinology 2021
The Endocrine Society
Medical and Graduate School
Ruth L. Kirschstein National Research Service Awards 2016-2018
National Institute of Diabetes and Digestive and Kidney Diseases
- An individual fellowship for medical and graduate school
Medical Scientist Training Program 2009-2018
National Institute of General Medical Sciences
- Full merit scholarship towards medical and graduate school
Howard Hughes Medical Institutes Med into Grad Initiative 2010-2011
- Funding to support the first year of graduate school in the Translational Biology and Molecular Medicine department
Community Service Award 2017
Medical Scientist Training Program
- Awarded for outstanding service for the entirety of the Medical Science Training Program
Oral presentation 2016
At the American Association of Physicians, the American Society of Clinical Investigation, American Physician Scientist Association joint meeting
American Physician Scientist Association Travel Award 2016
- Joint meeting of the American Association of Physicians, the American Society of Clinical Investigation, American Physician Scientist Association, Chicago, IL.
Undergraduate
Phi Beta Kappa 2009
Honor Society
Meyerhoff Scholar 2005-2009
- A full merit scholarship towards undergraduate studies for students interested in underrepresented minorities in STEM
Howard Hughes Medical Institute Scholar 2006-2009
- A full merit scholarship towards undergraduate studies and undergraduate research projects
MARC U*STAR 2007-2009
(Minority Access to Research Careers, Undergraduate Student Training in Academic Research)
- A full merit scholarship for underrepresented minorities interested in pursing careers in STEM that supported undergraduate studies and research projects
Federation of American Societies for Experimental Biology Travel Award 2006
- Support for travel and poster presentation at the Annual Biomedical Research Conference For Minority Students
Golden Key International Honor Society
Other Links
- Lazar Lab
Perelman School of Medicine at the University of Pennsylvania, Institute for Diabetes, Obesity, and Metabolism, 12-102 Smilow Translational Research Center
- Department Profile – Division of Endocrinology, Diabetes and Metabolism
Penn medicine Department of Medicine Fellow Profile
- Penn Medicine Physician Profile
Penn Medicine – Endocrinology
- Department Profile – University of Pennsylvania Medicine
NRSA Postdoctoral Fellow of Medicine
- US News Health Profile
Public Health profile